The Stratigraphic Record of Pre-breakup Geodynamics: Evidence from the Barrow Delta, offshore Northwest Australia

The structural and stratigraphic evolution of rift basins and passive margins has been widely studied, with many analyses demonstrating that delta systems can provide important records of post-rift geodynamic processes. However, the apparent lack of ancient syn-breakup delta systems and the paucity of seismic imaging across continent-ocean boundaries means the transition from continental rifting to oceanic spreading remains poorly understood. The Early Cretaceous Barrow Group of the North Carnarvon Basin, offshore NW Australia was a major deltaic system that formed during the latter stages of continental rifting, and represents a rich sedimentary archive, documenting uplift, subsidence and erosion of the margin. We use a regional database of 2D and 3D seismic and well data to constrain the internal architecture of the Barrow Group. Our results highlight three major depocentres: the Exmouth and Barrow sub-basins, and southern Exmouth Plateau. Over-compaction of pre-Cretaceous sedimentary rocks in the South Carnarvon Basin, and pervasive reworking of Permian and Triassic palynomorphs in the offshore Barrow Group, suggests that the onshore South Carnarvon Basin originally contained a thicker sedimentary succession, which was uplifted and eroded prior to breakup. Backstripping of sedimentary successions encountered in wells in the Exmouth Plateau depocentre indicate anomalously rapid tectonic subsidence (≤0.24 mm yr-1) accommodated Barrow Group deposition, despite evidence for minimal, contemporaneous upper crustal extension. Our results suggest that classic models of uniform extension cannot account for the observations of uplift and subsidence in the North Carnarvon Basin, and may indicate a period of depth-dependent extension or dynamic topography preceding breakup

Phenotypic mixing between strains of tobacco mosaic virus

RESP-640

The relative concentration of infective intact virus and RNA of four strains of tobacco mosaic virus as influenced by temperature

RESP-640

In vivo phenotypic mixing between two strains of tobacco mosaic virus

RESP-632

The crustal structure of the Anatolian Plate from receiver functions and implications for the uplift of the Central and Eastern Anatolian plateaus

Understanding the crustal structure of the Anatolian Plate has important implications for its formation and evolution, including the extent to which its high elevation is maintained isostatically. However, the numerous teleseismic receiver function studies from which Anatolian Moho depths have been obtained return results that differ by ≤21 km at some seismograph stations. To address this issue, we determine Moho depth and bulk crustal VP/VS ratio (κ) at 582 broadband seismograph stations, including ∼100 for which H-κ results have not been reported previously. We use a modified H-κ stacking method in which a final solution is selected from a suite of up to 1000 repeat H-κ measurements, each calculated using randomly-selected receiver functions and H-κ input parameters. Ten quality control criteria that variously assess the final numerical result, the receiver function data set, and the extent to which the results are clustered tightly, are used to determine station quality. By refining Moho depth constraints, including identifying 182 stations, analysed previously, where H-κ stacking yields unreliable results (particularly in Eastern Anatolia and the rapidly-uplifting Taurides), our new crustal model (ANATOLIA-HK21) provides fresh insight into Anatolian crustal structure and topography. Changes in Moho depth within the Anatolian Plate occur on a shorter length-scale than has sometimes previously been assumed. For example, crustal thickness decreases abruptly from >40 km in the northern Kirsehir block to <32 km beneath the Central Anatolian Volcanic Province and Tuz Golu basin. Moho depth increases from 30-35 km on the Arabian Plate to 35-40 km across the East Anatolian Fault into Anatolia, in support of structural geological observations that Arabia-Anatolia crustal shortening was accommodated primarily on the Anatolian, not Arabian, Plate. However, there are no consistent changes in Moho depth across the North Anatolian Fault, whose development along the Intra-Pontide and İzmir-Ankara-Erzincan suture zones was more likely the result of contrasts in mantle lithospheric, not crustal, structure. While the crust thins from ∼45 km below the uplifted Eastern Anatolian Plateau to ∼25 km below lower-lying western Anatolia, Moho depth is generally correlated poorly with elevation. Residual topography calculations confirm the requirement for a mantle contribution to Anatolian Plateau uplift, with localised asthenospheric upwellings in response to slab break-off and/or lithospheric dripping/delamination example candidate driving mechanisms

Multigenetic origin of the X-discontinuity below continents: insights from African receiver functions

Constraints on chemical heterogeneities in the upper mantle may be derived from studying the seismically observable impedance contrasts that they produce. Away from subduction zones, several causal mechanisms are possible to explain the intermittently observed X-discontinuity (X) at 230–350 km depth: the coesite-stishovite phase transition, the enstatite to clinoenstatite phase transition, and/or carbonated silicate melting, all requiring a local enrichment of basalt. Africa hosts a broad range of terranes, from Precambrian cores to Cenozoic hotspots with or without lowermost mantle origins. With the absence of subduction below the margins of the African plate for >0.5 Ga, Africa presents an ideal study locale to explore the origins of the X. Traditional receiver function (RF) approaches used to map seismic discontinuities, such as common conversion-point stacking, ignore slowness information crucial for discriminating converted upper mantle phases from surface multiples. By manually assessing depth and slowness stacks for 1° radius overlapping bins, normalized vote mapping of RF stacks is used to robustly assess the spatial distribution of converted upper mantle phases. The X is mapped beneath Africa at 233–340 km depth, revealing patches of heterogeneity proximal to mantle upwellings in Afar, Canaries, Cape Verde, East Africa, Hoggar, and Réunion with further observations beneath Cameroon, Madagascar, and Morocco. There is a lack of an X beneath southern Africa and strikingly, the magmatic eastern rift branch of the southern East African Rift. With no relationships existing between depth and amplitudes of observed X and estimated mantle temperatures, multiple causal mechanisms are required across a range of continental geodynamic settings

Seismic tomographic imaging of the Eastern Mediterranean Mantle: Implications for terminal-stage subduction, the uplift of Anatolia, and the development of the North Anatolian Fault

The Eastern Mediterranean captures the eastwest transition from active subduction of Earth'soldest oceanic lithosphere to continental collision, making it an ideal location to study terminalstagesubduction. Asthenospheric or subductionrelated processes are the main candidates for the region's ∼2kmuplift and Miocene volcanism; however, their relative importance is debated. To address these issues, wepresent new P and S wave relative arrivaltime tomographic models that reveal fast anomalies associatedwith an intact Aegean slab in the west, progressing to a fragmented, partially continental, Cyprean slabbelow central Anatolia. We resolve a gap between the Aegean and Cyprean slabs, and a horizontal tear in theCyprean slab below the Central Anatolian Volcanic Province. Below eastern Anatolia, the completelydetached “Bitlis” slab is characterized by fast wave speeds at ∼500 km depth. Assuming slab sinkingrates mirror ArabiaAnatolia convergence rates, the Bitlis slab's location indicates an Oligocene (∼26 Ma)breakoff. Results further reveal a strong velocity contrast across the North Anatolian Fault likelyrepresenting a 40–60 km decrease in lithospheric thickness from the Precambrian lithosphere north of thefault to a thinned Anatolian lithosphere in the south. Slow uppermostmantle wave speeds below activevolcanoes in eastern Anatolia, and ratios of P to S wave relative traveltimes, indicate a thin lithosphere andmelt contributions. Positive central and eastern Anatolian residual topography requires additional supportfrom hot/buoyant asthenosphere to maintain the 1–2 km elevation in addition to an almost absentlithospheric mantle. Smallscale fast velocity structures in the shallow mantle above the Bitlis slab maytherefore be drips of Anatolian lithospheric mantle

Cytotoxic Action of Carboxyborane Heterocyclic Amine Adducts

The heterocyclic carboxyborane amines were found to be potent cytotoxic agents in the murine L1210 lymphoid leukemia and human HeLa suspended carcinoma cells. These agents were observed to inhibit HeLa DNA topoisomerase II activity ~ 200 μM and L1210 topoisomerase II activity ≥ 100 μM. These agents did not cause DNA protein linked breaks themselves, but upon incubation for 14-24 hr did enhance the ability of VP-16 to cause cleavable complexes. The heterocyclic amineboranes inhibited DNA synthesis and caused DNA strand scission. They were additive with VP-16 in affording these results as well as inhibiting colony growth of L1210 cells after co-incubation for 1 hr. The agents inhibited in vitro PKC phosphorylation of both L1210 lymphoid leukemia and human topoisomerase II enzyme

Seismicity and crustal structure of the southern main Ethiopian rift: new evidence from Lake Abaya

The Main Ethiopian Rift (MER) has developed during the 18 Ma-Recent separation of the Nubian and Somalian plates. Extension in its central and northern sectors is associated with seismic activity and active magma intrusion, primarily within the rift, where shallow (urn:x-wiley:15252027:media:ggge22586:ggge22586-math-00015 km) seismicity along magmatic centers is commonly caused by fluid flow through open fractures in hydrothermal systems. However, the extent to which similar magmatic rifting persists into the southern MER is unknown. Using data from a temporary network of five seismograph stations, we analyze patterns of seismicity and crustal structure in the Abaya region of the southern MER. Magnitudes range from 0.9 to 4.0; earthquake depths are 0–30 km. urn:x-wiley:15252027:media:ggge22586:ggge22586-math-0002 ratios of urn:x-wiley:15252027:media:ggge22586:ggge22586-math-00031.69, estimated from Wadati diagram analysis, corroborate bulk-crustal urn:x-wiley:15252027:media:ggge22586:ggge22586-math-0004 ratios determined via teleseismic P-to-S receiver function H-urn:x-wiley:15252027:media:ggge22586:ggge22586-math-0005 stacking and reveal a relative lack of mafic intrusion compared to the MER rift sectors to the north. There is a clear association of seismicity with the western border fault system of the MER everywhere in our study area, but earthquake depths are shallow near Duguna volcano, implying a shallowed geothermal gradient associated with rift valley silicic magmatism. This part of the MER is thus interpreted best as a young magmatic system that locally impacts the geothermal gradient but that has not yet significantly modified continental crustal composition via rift-axial magmatic rifting

Body-wave tomographic imaging of the Turkana Depression: Implications for rift development and plume-lithosphere interactions

The Turkana Depression, a topographically-subdued, broadly-rifted zone between the elevated East African and Ethiopian plateaus, disrupts the N–S, fault-bounded rift basin morphology that characterizes most of the East African Rift. The unusual breadth of the Turkana Depression leaves unanswered questions about the initiation and evolution of rifting between the Main Ethiopian and Eastern rifts. Hypotheses explaining the unusually broad, low-lying area include superposed Mesozoic and Cenozoic rifting and a lack of mantle lithospheric thinning and dynamic support. To address these issues, we have carried out the first body-wave tomographic study of the Depression’s upper mantle. Seismically-derived temperatures at 100 km depth exceed petrological estimates, suggesting the presence of mantle melt, although not as voluminous as the Main Ethiopian Rift, contributes to velocity anomalies. A NW–SE-trending high wavespeed band in southern Ethiopia at urn:x-wiley:15252027:media:ggge22580:ggge22580-math-0001200 km depth is interpreted as refractory Proterozoic lithosphere which has likely influenced the localization of both Mesozoic and Cenozoic rifting. At urn:x-wiley:15252027:media:ggge22580:ggge22580-math-0002100 km depth below the central Depression, a single localized low wavespeed zone is lacking. Only in the northernmost Eastern Rift and southern Lake Turkana is there evidence for focused low wavespeeds resembling the Main Ethiopian Rift, that bifurcate below the Depression and broaden approaching southern Ethiopia further north. These low wavespeeds may be attributed to melt-intruded mantle lithosphere or ponded asthenospheric material below lithospheric thin-spots induced by the region's multiple rifting phases. Low wavespeeds persist to the mantle transition zone suggesting the Depression may not lack mantle dynamic support in comparison to the two plateaus